Adolfo garcia sastre biography of mahatma

Adolfo García-Sastre

Spanish and American academic

Adolfo García-Sastre,(born in Burgos, 10 October ) is a Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City.

His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology.[1]

García-Sastre is the author of more than publications.

Biography

Born in Burgos, Spain, García-Sastre earned his PhD at the University of Salamanca.[citation needed] His research interest has been focused on the molecular biology of influenza viruses and several other negative-strandRNA viruses.

His contributions to his field have included the generation and evaluation of influenza virus vectors as potential vaccine candidates against infectious diseases, including malaria and AIDS, as well as the development (with Peter Palese) of the first reverse-genetic approaches for the production of infectious recombinant influenza viruses from plasmidDNA – research which has resulted in techniques which are now routinely used with many negative strand RNA viruses.

He was the first to identify the biological role of the non-structural NS1 Influenza Protein during infection, the first to describe and provide a molecular analysis of a viral-encoded IFN antagonist among negative strand RNA viruses,[1] and the first to demonstrate that the M1 protein of the influenza virus determines its morphology.

In , as principal investigator of an NIAID program project grant, García-Sastre and his team made headlines when they reconstructed the extinct pandemic influenza virus.[2]

García-Sastre is an editor for the Journal of Experimental Medicine and PLOS Pathogens, and he sits on the editorial boards of the Journal of Virology, Virology, Virus Research and the Journal of General Virology.

Adolfo garcia sastre biography of mahatma Tools Tools. A major focus of the lab is on influenza virus research. Education University Salamanca , Bachelor of Science. These studies led to the generation of attenuated influenza viruses containing defined mutations in their IFN antagonist protein that might prove to be optimal live vaccines against influenza.

In , he co-organized the International Course on Viral Vectors in Heidelberg, Germany, which was sponsored by the Federation of European Biochemical Societies (FEBS), as well as the first Research Conference on Orthomyxoviruses, also in , which was held in the Netherlands and sponsored by the European Scientific Working Group on Influenza.[2] He is a co-founder of Vivaldi Biosciences and a member of the company's Scientific Advisory board[3] and is the leader of the basic research component on the NIAID-funded Viral Therapeutics and Pathogenesis of the North East Biodefense Center proposal.[4] He was among the first members of the Vaccine Study Section of the National Institutes of Health.[5] He is also principal investigator for the Center for Research on Influenza Pathogenesis, one of five NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS).

He was elected to the National Academy of Sciences in [6]

Patents

García-Sastre holds 7 patents:[7]

Number Title
Recombinant newcastle disease virus RNA expression systems and vaccines[8]
Novel methods and Interferon deficient substrates for the propagation of virues[9]
Recombinant negative strand RNA virus expression systems and vaccines[10]
Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals[11]
Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents[12]
Genetically Engineered Swine Influenza Virus and Uses Thereof[13]
Genetically Engineered Equine Influenza Virus and Uses Thereof[14]

Publications

Partial List:

  • Mueller, S.

    N.; Langley, W. A.; Carnero, E.; Garcia-Sastre, A.; Ahmed, R. (). "Immunization with Live Attenuated Influenza Viruses That Express Altered NS1 Proteins Results in Potent and Protective Memory CD8+ T-Cell Responses". Journal of Virology. 84 (4): – doi/JVI PMC&#; PMID&#;

  • Martinez-Sobrido, L.; Cadagan, R.; Steel, J.; Basler, C.

    F.; Palese, P.; Moran, T. M.; Garcia-Sastre, A. (). "Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies". Journal of Virology. 84 (4): – doi/JVI PMC&#; PMID&#;

  • Nistal-Villán, E.; García-Sastre, A. (). "Attacking the flu: New prospects for the rational design of antivirals".

    Nature Medicine. 15 (11): – doi/nm PMC&#; PMID&#;

  • Babiuk, S.; Albrecht, R.; Berhane, Y.; Marszal, P.; Richt, J. A.; Garcia-Sastre, A.; Pasick, J.; Weingartl, H. (). " and H1N1 influenza viruses are not pathogenic in birds". Journal of General Virology. 91 (2): – doi/vir PMC&#; PMID&#;
  • Baum, A.; García-Sastre, A.

    (). "Induction of type I interferon by RNA viruses: Cellular receptors and their substrates". Amino Acids. 38 (5): – doi/s PMC&#; PMID&#;

  • Tscherne, D. M.; Manicassamy, B.; García-Sastre, A. (). "An enzymatic virus-like particle assay for sensitive detection of virus entry". Journal of Virological Methods.

    (2): – doi/et PMC&#; PMID&#;

  • Gannagé, M.; Dormann, D.; Albrecht, R.; Dengjel, J. R.; Torossi, T.; Rämer, P. C.; Lee, M.; Strowig, T.; Arrey, F.; Conenello, G.; Pypaert, M.; Andersen, J.; García-Sastre, A.; Münz, C. (). "Matrix Protein 2 of Influenza a Virus Blocks Autophagosome Fusion with Lysosomes". Cell Host & Microbe.

    6 (4): – doi/ PMC&#; PMID&#;

  • Steel, J.; Staeheli, P.; Mubareka, S.; Garcia-Sastre, A.; Palese, P.; Lowen, A. C. (). "Transmission of Pandemic H1N1 Influenza Virus and Impact of Prior Exposure to Seasonal Strains or Interferon Treatment". Journal of Virology. 84 (1): 21– doi/JVI PMC&#; PMID&#;
  • Richt, J.

    E. A.; García-Sastre, A. (). "Attenuated Influenza Virus Vaccines with Modified NS1 Proteins". Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology.

  • Vol.&#; pp.&#;– doi/_9. ISBN&#;. PMID&#;

  • Kochs, G.; Martinez-Sobrido, L.; Lienenklaus, S.; Weiss, S.; Garcia-Sastre, A.; Staeheli, P. (). "Strong interferon-inducing capacity of a highly virulent variant of influenza a virus strain PR8 with deletions in the NS1 gene". Journal of General Virology.

    90 (12): – doi/vir PMC&#; PMID&#;

  • Guo, H.; Kumar, P.; Moran, T. M.; Garcia-Sastre, A.; Zhou, Y.; Malarkannan, S. ().

    Other viruses being studied include Zika virus, Dengue virus, West Nile virus, and Crimean-Congo hemorrhagic fever virus. Adolfo Garcia-Sastre Edit Profile molecular virologist microbiology educator Adolfo Garcia-Sastre, Spanish molecular virologist, microbiology educator. These studies led to the generation of attenuated influenza viruses containing defined mutations in their IFN antagonist protein that might prove to be optimal live vaccines against influenza. The team has developed several techniques reverse genetics , which allow for the genetic manipulation of the genomes of several virus families including influenza virus and Newcastle disease virus.

    "The functional impairment of natural killer cells during influenza virus infection". Immunology and Cell Biology. 87 (8): – doi/icb PMC&#; PMID&#;

  • Martinez-Sobrido, L.; Emonet, S.; Giannakas, P.; Cubitt, B.; Garcia-Sastre, A.; De La Torre, J. C. (). "Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus".

    Journal of Virology. 83 (21): – doi/JVI PMC&#; PMID&#;

  • Billharz, R.; Zeng, H.; Proll, S. C.; Korth, M. J.; Lederer, S.; Albrecht, R.; Goodman, A. G.; Rosenzweig, E.; Tumpey, T. M.; García-Sastre, A.; Katze, M. G. (). "The NS1 Protein of the Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways".

    Journal of Virology. 83 (20): – doi/JVI PMC&#; PMID&#;

  • Bolland, S.; Garcia-Sastre, A. ().

    Adolfo garcia sastre biography of mahatma gandhi The laboratory is using both hypothesis-driven and systems biology based approaches to understand virus pathogenesis and to develop improved antivirals and vaccines. Connections Add photo. Toggle the table of contents. Home Profiles.

    "Vicious circle: Systemic autoreactivity in Ro52/TRIMdeficient mice". Journal of Experimental Medicine. (8): – doi/jem PMC&#; PMID&#;

  • Kuri, T.; Zhang, X.; Habjan, M.; Martinez-Sobrido, L.; Garcia-Sastre, A.; Yuan, Z.; Weber, F. (). "Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation".

    Journal of General Virology. 90 (11): – doi/vir PMC&#; PMID&#;

  • Frias-Staheli, N.; Giannakopoulos, N. V.; Kikkert, M.; Taylor, S. L.; Bridgen, A.; Paragas, J.; Richt, J. A.; Rowland, R. R.; Schmaljohn, C. S.; Lenschow, D. J.; Snijder, E. J.; García-Sastre, A.; Virgin, H. W. (). "Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISGDependent Innate Immune Responses".

    Cell Host & Microbe. 2 (6): – doi/ PMC&#; PMID&#;

  • Vigil, A.; Park, M. -S.; Martinez, O.; Chua, M. A.; Xiao, S.; Cros, J. F.; Martínez-Sobrido, L.; Woo, S. L. C.; García-Sastre, A. (). "Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus". Cancer Research. 67 (17): – doi/CAN PMID&#;
  • Mibayashi, M.; Martinez-Sobrido, L.; Loo, Y.

    -M.; Cardenas, W. B.; Gale, M.; Garcia-Sastre, A. (). "Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza a Virus". Journal of Virology. 81 (2): – doi/JVI PMC&#; PMID&#;

  • Tumpey, T. M.; Maines, T. R.; Van Hoeven, N.; Glaser, L.; Solórzano, A.; Pappas, C.; Cox, N.

    J.; Swayne, D. E.; Palese, P.; Katz, J. M.; García-Sastre, A. (). "A Two-Amino Acid Change in the Hemagglutinin of the Influenza Virus Abolishes Transmission". Science. (): – BibcodeSciT. doi/science PMID&#; S2CID&#;

  • Richt, J. A.; Lekcharoensuk, P.; Lager, K. M.; Vincent, A. L.; Loiacono, C. M.; Janke, B. H.; Wu, W.

    -H.; Yoon, K. -J.; Webby, R. J.; Solórzano, A.; García-Sastre, A. ().

    Adolfo Garcia-Sastre | Mount Sinai - New York: Reverse genetics are also being utilized to generate virus vectors based on influenza virus and Newcastle disease virus. Career Add photo. In other projects. Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents [ 12 ].

    "Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine". Journal of Virology. 80 (22): – doi/JVI PMC&#; PMID&#;

  • Tumpey, T. M.; Basler, C. F.; Aguilar, P. V.; Zeng, H.; Solórzano, A.; Swayne, D. E.; Cox, N. J.; Katz, J. M.; Taubenberger, J. K.; Palese, P.; García-Sastre, A.

    (). "Characterization of the Reconstructed Spanish Influenza Pandemic Virus". Science. (): 77– BibcodeSciT. CiteSeerX&#; doi/science PMID&#; S2CID&#;

  • Munoz-Jordan, J. L.; Sánchez-Burgos, G. G.; Laurent-Rolle, M.; García-Sastre, A. ().

  • Adolfo García-Sastre | Mount Sinai School of Medicine ...
  • Settings
  • Adolfo Garcia-Sastre (born October 10, 1964), Spanish ...
  • Adolfo Garcia-Sastre - Icahn School of Medicine at Mount Sinai
  • Adolfo Garcia-Sastre - Icahn School of Medicine at Mount Sinai

    • "Inhibition of interferon signaling by dengue virus". Proceedings of the National Academy of Sciences. (24): – BibcodePNASM. doi/pnas PMC&#; PMID&#;

  • Basler, C. F.; Reid, A. H.; Dybing, J. K.; Janczewski, T. A.; Fanning, T. G.; Zheng, H.; Salvatore, M.; Perdue, M. L.; Swayne, D. E.; García-Sastre, A.; Palese, P.; Taubenberger, J.

    K. (). "Sequence of the pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the NS genes".

    Biography of mahatma gandhi He was elected to the National Academy of Sciences in Archived from the original on 21 November University of Salamanca. Achievements Add photo.

    Proceedings of the National Academy of Sciences. 98 (5): – doi/pnas PMC&#; PMID&#;

  • Garciasastre, A. (). "Inhibition of Interferon-Mediated Antiviral Responses by Influenza a Viruses and Other Negative-Strand RNA Viruses". Virology. (2): – doi/viro PMID&#;
  • Fodor, E.; Devenish, L.; Engelhardt, O.

    G.; Palese, P.; Brownlee, G. G.; García-Sastre, A. (). "Rescue of Influenza a Virus from Recombinant DNA". Journal of Virology. 73 (11): – doi/JVI PMC&#; PMID&#;

References

External links